Bioengineering and Toxicology Seminar Academic Year 2022-23

Fall 2022

Sep 9, 2022 - 12:00 PM 32-155

Engineering DNA Origami Nanoparticles as a Modular Vaccine Platform to Investigate Humoral Immunity

MultiExM: Expansion Microscopy Adapted to the Well Plate

Sep 16, 2022 - 12:00 PM 32-155

Antibiotics in Lyme Arthritis: A Humoral Immune Modeling Approach to Dissecting Outcomes

Engineering Reporters for Host-mediated Killing of Mycobacteria

Sep 23, 2022 - 12:00 PM 32-141

Stitch-seq: A Facile and High-throughput Perturbation Sequencing Method

Intestinal Mucins Reduce the Virulence Potential of Enterohemorrhagic Escherichia Coli

Sep 30, 2022 - 12:00 PM 32-155

A Platform for the Generation of Targeted, Orally-available Cyclotide Therapeutics

Precise Cut-and-Paste DNA Insertion with Engineered Type V-K CRISPR-associated Transposases

Oct 7, 2022 - 12:00 PM 32-155

Molecular Recording Enables High-throughput Measurement of Biomolecular Activities

Exploring the Synthetic Signaling Space of Cell Fate Decision

Oct 14, 2022 - 12:00 PM 32-155

Pooled Genetic Screens to Interrogate TCR Signaling Networks

Substrate Positioning Distinguishes Halogenases and Hydroxylases

Oct 21, 2022 - 12:00 PM 32-155

Pooled Optical Genetic Screens for Huntington’s Disease Research

Leveraging Novel Blood Exchange in Mice: Interactions of Gut Microbiome, Immune System, and Tumors

Oct 28, 2022 - 12:00 PM 32-155

Biophysical Characterization of Cytotoxic T cell Heterogeneity in Cancer Progression

Profiling Protease Dysregulation in Lung Cancer with Protease-activatable Nanotechnologies

Nov 4, 2022 - 12:00 PM 32-155

Engineering Bacteria for the Biodegradation and Upcycling of Plastics

A Scalable Toolkit for Multidimensional Spatiotemporal Modeling of Spatial Transcriptomics

Nov 18, 2022 - 12:00 PM 32-155

Applying Proximity Labeling to Study the Pathogen-containing Phagosome

Engineering Precise, Robust Gene Expression During Cell-fate Transitions

Dec 2, 2022 - 12:00 PM 32-155

Controlling Subpopulation Fractions of Bistable Biomolecular Circuits: Theory, Design, Simulation

Live Tissue Transparency: Engineering High Refractive Index Proteins as Optical Tools

Dec 9, 2022 - 12:00 PM 32-155

Engineering Strategies to Modulate CD45 Signaling for Cancer Immunotherapy

Engineering Bidirectional Plant-microbe Signaling to Combat Plant Disease

Dec 16, 2022 - 12:00 PM 32-155

Characterizing Bidirectional Promoter Transcriptional Dynamics Using Live-cell Nascent RNA Imaging

Dynamics of ZNF143’s Nuclear Search Revealed Using Live-cell Imaging

Spring 2023

Feb 10, 2023 - 12:00 PM 32-155

Profiling and Perturbing Epithelial-Mesenchymal Plasticity in Cancer

Feb 17, 2023 - 12:00 PM 32-155

A Metabolism-based Approach to Shifting the Female Genital Tract Microbiome

Engineering a Physiologically Relevant In vitro Mucosal Barrier Model via Organoid Fusion

Feb 24, 2023 - 12:00 PM 32-155

Investigating Effects of AXL Inhibition on the Tumor Immune Microenvironment

Taking a Pause: Uncovering the Role of RNA Structure in Mammalian Transcription

Mar 10, 2023 - 12:00 PM 32-155

Region Capture Micro-C Reveals Coalescence of Enhancers & Promoters into Nested Microcompartments

Dynamic Bottom-up Dissection of Chromatin Looping and Gene Regulation

Mar 17, 2023 - 12:00 PM 32-155

Investigating Virus-like Particles as Yeast Display Binding Reagents

Modification of mRNA Poly(A) Tails to Augment Expression

Mar 24, 2023 - 12:00 PM 32-155

DNA Nanostructures for Targeted Therapeutic Delivery

Immunopeptidomics Reveals Determinants of Antigen Presentation in Tuberculosis

Apr 7, 2023 - 12:00 PM 32-155

Engineering Microphysiological Systems to Investigate Endometriotic Lesion Vascularization

Engineering Retroviruses for Antigen-specific Gene Delivery to T cells

Apr 14, 2023 - 12:00 PM 32-155

Genetically-encoded Reporter System for Remote Sensing

Engineered Nitrogen-fixing Bacteria as a Low-cost and Low-carbon Alternative to Synthetic Fertilizer

Apr 21, 2023 - 12:00 PM 32-155

Enhancing Cancer Immunotherapy Through Enzymatic Programming of Intratumoral Reactive Oxygen Species

A Novel Gain of Signal Reporter Assay for Detecting Targeted Protein Degradation

Apr 28, 2023 - 12:00 PM 32-155

Leveraging CAR Libraries and Single-cell Omics to Deeply Characterize CAR Signaling Space

Engineering a Physiologically Relevant Vascularized Model of Hepatic Insulin Resistance

May 5, 2023 - 12:00 PM 32-155

Mucin Glycans are Host-Derived Immunomodulators of Neutrophils

Beyond the Inhibition Paradigm: Modulating Transcription Through Protein Degradation

May 12, 2023 - 12:00 PM 32-155

Exploring the Biochemical Diversity of the RNA-guided Nuclease TnpB

Upcycling Plastic Waste to Food with Diverse Bacteria