Bioengineering and Toxicology Seminar Academic Year 2023-24

Spring 2024

Feb 23, 2024 - 12:00 PM 32-155

Stitch-seq: A Facile and High-throughput Perturbation Sequencing Method

Applying Activity-based Nanotechnologies Towards Lung Cancer Interception

Mar 8, 2024 - 12:00 PM 32-155

An Ultra-high-throughput Method for Measuring Biomolecular Activities

Engineering Strategies to Modulate CD45 for Cancer Immunotherapy

Mar 15, 2024 - 12:00 PM 32-155

Proximity Labeling as an Approach to Study the Phagosome Proteome

Programmable Display of Vaccine Immunogens on Inert DNA Origami Scaffolds

Mar 22, 2024 - 12:00 PM 32-155

Characterizing Bidirectional Promoter Transcriptional Dynamics Using Live-cell Nascent RNA Imaging

Putative Looping Factor ZFP143 is an Essential Transcriptional Regulator with No Looping Function

Apr 5, 2024 - 12:00 PM 32-155

Bimodal Cell Mass Distribution Separates CD8+ T Cells into Two Types with Divergent Differentiation Dynamics

Elucidating the Cellular and Molecular Basis of Anti-tumor Peptide Alarm Therapy

Apr 12, 2024 - 12:00 PM 32-155

Reconstructing Signaling History and Spatial Organization of Single Cells via Deep Learning

Elucidating B Lymphocyte Control of Humoral Response: A Systems Biology Approach

Apr 19, 2024 - 12:00 PM 32-155

Self-labeling Mtb Enables Identification and Enrichment of Mtb-derived Proteins from Infected Macrophages

Chemostatic System for Culture of Patient Derived Colorectal Cancer Organoids

Apr 26, 2024 - 12:00 PM 32-155

Engineering Bacteria for Bioassimilation and Upcycling of Nylon Monomers

Engineering Synthetic Plant-Microbe Interactions for Plant Disease Resistance

May 3, 2024 - 12:00 PM 32-155

Dynamic Charge Distribution as a Key Driver of Catalytic Reactivity in an Artificial Enzyme

Tuning a Compact Genetic Circuit for Precise Gene Expression in Primary Cells

May 10, 2024 - 12:00 PM 32-155

Pooled Optical Proteomic Profiling Platform to Study Huntington’s Disease Pathways

Characterizing High Refractive Index Proteins as Optical Tools

May 17, 2024 - 12:00 PM 32-141

Precision Genome Editing with DNA-dependent Polymerases and HUH Endonucleases

HiExM: High-throughput Expansion Microscopy Enables Scalable Super-resolution Imaging

May 24, 2024 - 12:00 PM 32-155

Engineering a Knottin Inhibitor of Tumor Necrosis Factor

Uncovering Translational Mechanisms of Control Over Virulence in Enterohemorrhagic E. coli O157:H7 (EHEC)

Fall 2023

Sep 15, 2023 - 12:00 PM 32-155

Engineering a Compact Epigenome Editor to Treat Fatal Prion Disease

Boosting CAR T Cells for a Universal Solid Tumor Therapy

Sep 22, 2023 - 12:00 PM 32-155

Quantifying Antigen Presentation Dynamics During Tumor Cell and Macrophage Evolution in Glioblastoma

Sep 29, 2023 - 12:00 PM 32-155

Remote Electrogenetic Induction of Engineered Therapeutic Bacteria

From Silicon to Cells: Engineering Bacteria for Distributed Computing

Oct 6, 2023 - 12:00 PM 32-155

Context-dependent Macrophage Repolarization

Structure-based Site-directed Mutagenesis of T cell Receptors (TCRs) to Improve TCR-T cell Therapies

Oct 13, 2023 - 12:00 PM 32-155

A Stonefish-inspired Device for Oral Delivery of Biologics

High-Throughput Genetic Perturbation Screens with In Situ RNA Sequencing

Oct 20, 2023 - 12:00 PM 32-155

Exploring the Virome for In Vivo RNA Delivery

Uncertainty Quantified Discovery of Chemical Reaction Systems via Scientific Machine Learning

Oct 27, 2023 - 12:00 PM 32-155

Tracking RNA Vaccine-derived Antigen Biodistribution and Kinetics In Vivo

Formulating Immune Protection: Enhance Humoral Response Through Vaccine Engineering

Nov 3, 2023 - 12:00 PM 32-155

Identifying Targeted Therapeutic Candidates in Brain Tumors

Chaperone Competition Affects Performance of Bacterial Synthetic Genetic Circuits

Nov 17, 2023 - 12:00 PM 32-155

Pumping the Brakes: Modulating Intratumoral Cytokine Signaling to Bolster Immunological Memory

Identifying Cross-reactive Peptide Mimotopes for Autoreactive T cells in Type 1 Diabetes

Dec 1, 2023 - 12:00 PM 32-155

Engineering a Biomining Platform for Lithium Extraction

Continuous Harvesting of Viral Vectors from Perfusion Culture Using Spiral Inertial Microfluidics

Dec 8, 2023 - 12:00 PM 32-155

Development of a Dual Imaging System to Measure Functional Connectivity between the Brain and Gut

Modeling Drugs’ On- and Off-target Effects on Tumor Cell Signaling Using Artificial Neural Networks

Dec 15, 2023 - 12:00 PM 32-155

Investigating Interactions between Cohesin-mediated Chromatin Looping and Transcription

Reprogrammable RNA-guided Nucleases in Eukaryotes and Their Viruses