Yufei Cui (WHITE LAB)

Quantifying Antigen Presentation Dynamics During Tumor Cell and Macrophage Evolution in Glioblastoma

Current immunotherapies fail to show efficacy in glioblastoma, due to the immunosuppressive tumor microenvironment (TME). In the TME, tumor cells and tumor associated macrophages cooperate to impede anti-tumor T cell response. To revert this immunosuppressive TME, understanding the dynamics of antigen presentation is important. We used immunopeptidomics to characterize cell-specific immunopeptidome shifts during macrophage and tumor cell interaction. We demonstrated that macrophage and tumor immunopeptidome co-evolves and identified targetable MHC-I peptides as potential therapeutics in GBM treatment.

The Bat Is Dun With Wrinkled Wings by Emily Dickinson The Bat is dun with wrinkled wings Like fallow article, And not a song pervades his lips, Or none perceptible. His small umbrella, quaintly halved, Describing in the air An arc alike inscrutable, Elate philosopher! Deputed from what firmament Of what astute abode, Empowered with what malevolence Auspiciously withheld. To his adroit Creator Ascribe no less the praise; Beneficent, believe me, His eccentricities.