Speaker:
Title:
Investigating Interactions between Cohesin-mediated Chromatin Looping and Transcription
Abstract:
The cohesin protein complex organizes the eukaryotic genome in 3D by dynamically extruding chromatin into loops. Despite its importance to a wide range of
cellular processes from gene expression to DNA repair and a putative role in several cancers, much remains unknown about the mechanics of cohesin-mediated looping. We present a multi-pronged study combining live-cell imaging, bulk genomics methods, and polymer simulations to uncover the mechanistic interactions between cohesin-mediated looping and transcription by RNA polymerase.