Speaker:
Title:
Bimodal Cell Mass Distribution Separates CD8+ T Cells into Two Types with Divergent Differentiation Dynamics
Abstract:
It is well known that T cell heterogeneity is critical in mounting a strong adaptive immune response. Using the lab’s suspended microchannel resonator (SMR) technology, we have observed two subpopulations in naïve CD8+ T cells by buoyant mass that cannot be distinguished by cell surface markers or other conventional physical measurements. In this study we aim to characterize these two subpopulations and identify their distinct differentiation dynamics by combining a novel cell sorting system with downstream functional assays.