Speaker:
Title:
Tracking RNA Vaccine-derived Antigen Biodistribution and Kinetics In Vivo
Abstract:
RNA vaccines have recently shown potential to increase the speed and reduce the cost of vaccine clinical trials. However, their mechanisms of action remain poorly understood. Specifically, the cell- and tissue-level localization of RNA-derived immunogens and their persistence following primary immunization remain unknown. Here, we propose novel genetically-tagged antigen constructs and primary cocktail staining modalities that can be used to define where RNA-derived antigens are transported and how long they persist following primary immunization.