Speaker:
Title:
Investigating Virus-like Particles as Yeast Display Binding Reagents
Abstract:
The development of targeted immunotherapies relies on the design of T cell receptors and antibodies with favorable binding properties. While yeast display as a means for directed evolution of immune receptors has been successful in creating breakthrough therapies for a number of diseases, many bottlenecks that limit further innovation remain. In this work we aim to address one of these bottlenecks by validating virus-like particles as a versatile yeast display binding reagent that can increase the throughput of TCR-pMHC binding experiments.