BATS

Date/Time:

Mar 24, 2023 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

DNA Nanostructures for Targeted Therapeutic Delivery

Abstract:

Targeted therapeutic delivery remains a significant challenge in nanomedicine. Nucleic acid nanoparticles are a promising nanomaterial for in vivo delivery that offer structural programmability, multivalent ligand presentation, multiplexed co-formulation of therapeutics, biocompatibility and controllable immunogenicity, and scalable manufacturing. However, as their targeting and therapeutic capabilities have yet to be fully understood, a ligand receptor system in hepatocytes is being leveraged to explore these properties of DNA nanostructures.

Speaker:

Title:

Immunopeptidomics Reveals Determinants of Antigen Presentation in Tuberculosis

Abstract:

Mycobacterium tuberculosis – the bacterium that causes tuberculosis – is a leading cause of infectious disease mortality, and clinicians lack a sufficiently protective vaccine. Immunity to M. tuberculosis depends on T cell recognition of peptides presented on major histocompatibility complexes (MHCs) by infected cells. Here, we describe a mass spectrometry-based approach to identify and quantify M. tuberculosis antigens presented on MHC class I and class II, revealing potential antigenic targets for more effective tuberculosis vaccines.