Speaker:
Title:
Enhancing Cancer Immunotherapy Through Enzymatic Programming of Intratumoral Reactive Oxygen Species
Abstract:
Increased cellular levels of reactive oxygen species (ROS) are observed as a result of many cancer cytotoxic treatments, despite only a fraction of them leading to the release of danger signals common to immunogenic cell death (ICD). As such, modulating the spatiotemporal dynamics of intratumoral ROS levels may enable the immunogenicity of tumor cell death to be tuned. Here, we examine the use of oxidase enzymes as an approach to probe ROS-ICD relationships and design treatment combinations that achieve stronger anti-tumor immunity.