BATS

Date/Time:

Apr 21, 2023 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Enhancing Cancer Immunotherapy Through Enzymatic Programming of Intratumoral Reactive Oxygen Species

Abstract:

Increased cellular levels of reactive oxygen species (ROS) are observed as a result of many cancer cytotoxic treatments, despite only a fraction of them leading to the release of danger signals common to immunogenic cell death (ICD). As such, modulating the spatiotemporal dynamics of intratumoral ROS levels may enable the immunogenicity of tumor cell death to be tuned. Here, we examine the use of oxidase enzymes as an approach to probe ROS-ICD relationships and design treatment combinations that achieve stronger anti-tumor immunity.

Speaker:

Title:

A Novel Gain of Signal Reporter Assay for Detecting Targeted Protein Degradation

Abstract:

Targeted protein degradation has the potential to expand therapeutic development to otherwise “undruggable” protein targets by regulating target abundance rather than activity. However, current methods to screen for effective degraders suffer from false positives and serve as a major bottleneck for the development of degrader therapies. Here, we develop a novel assay platform for more efficient identification and characterization of macromolecules capable of directing targeted degradation of the oncogenic phosphatase SHP2.