Pete Wishnok, PhD

Photo of Pete Wishnok.



(617) 253-6795
Senior Research Scientist


Biology and biological engineering are being increasingly driven by advances in bioanalytical techniques and instrumentation. My research is focused on applications of biological mass spectrometry for the characterization and quantitation of DNA and protein damage caused by exposure both to xenobiotic substances and to endogenous compounds that are formed during various metabolic pathways. DNA or protein modifications arising from endogenous substances, e.g., peroxynitrite, can provide valuable clues towards the biochemistry of their formation and often towards the subtle but important balances between essential vs damaging levels of nominally normal metabolites. Current projects include development of a nitrosothiol-specific fluorescent probe for visualizing nitric-oxide-related biomolecule modifications in brain tissue, a search for predictive or prognistic biomarkers of inflammatory bowel disease, and defining drug metabolism, metabolomics, and proteomics in a complex microphysiological system based on human cell cultures.

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