Peter Dedon, MD, PhD

Email: 

Office: 

56-787B

Phone: 

(617) 253-8017
Underwood-Prescott Professor of Biological Engineering

Research-at-a-glance: 

Structure- and screening-based antibiotic development
Translational control of cell response in cancer and infectious disease
Nucleic acid modifications in eukaryotes, prokaryotes and viruses
Inflammation and chemical immunology

Affiliations: 

Principal Investigator, Singapore-MIT Alliance for Research and Technology Infectious Disease IRG
Member, Center for Environmental Health Sciences
Faculty Member, Chulabhorn Graduate Research Institute
Guest Professor, Wuhan University
Fellow, American Chemical Society

Biography: 

Speaking fluent Minnesotan, Professor Peter Dedon began his scientific career with a BA degree in chemistry from St. Olaf College in Northfield, MN. He went on to earn MD and PhD degrees in pharmacology at the University of Rochester in 1987 and pursued postdoctoral research in chromatin biology at the University of Rochester and the chemical biology of DNA-cleaving anticancer drugs at Harvard Medical School. In 1991, Dedon joined the MIT faculty and helped create the Department of Biological Engineering in 1998. As an Underwood Prescott Professor in Biological Engineering, he is currently a PI in the SMART Infectious Disease group and a member of the MIT Center for Environmental Health Sciences, where he pursues research in infectious disease and inflammation.

Two images describing aspects of DNA and RNA modification research in the Dedon Lab.

Research: 

With longstanding interests in the chemical etiology of human disease, his current research program emphasizes the chemical biology of RNA and DNA modifications in microbial pathogenesis and human cancer biology. His research group recently discovered phosphorothioate modifications in bacterial genomes, including the human microbiome, with these DNA modifications conferring resistance to oxidative stress. In collaboration with Tom Begley, his group used a systems-level analysis to discover a mechanism of translational control of cell response involving reprogramming of tRNA modifications and selective translation of codon-biased mRNAs for stress response proteins. This translational response mechanism has now been observed in eukaryotes, prokaryotes and even RNA viruses, with the discovery of a novel tumor suppressor mechanism and pathways controlling bacterial dormancy. The Dedon Lab currently collaborates with New England Biolabs in DNA modification discovery, Novartis Institute for Tropical Disease in dengue virus biology, Wuhan and Jiao Tong Universities in China in phosphorothioate chemical biology, NUS and NTU in Singapore in Pseudomonas, malaria, tuberculosis, dengue biology and drug development, and the Universities of Albany and Florida in mechanisms of translational control of cell response.

Research Areas: 

Selected Publications:

T Y Chan, Clement, Madhu Dyavaiah, Michael S. DeMott, Koli Taghizadeh, Peter C. Dedon, and Thomas J. Begley. "A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress." PLoS Genet 6, no. 12 (2010): e1001247.
Wang, Lianrong, Shi Chen, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadeh, Otto X. Cordero, Michael Cutler, Sonia Timberlake et al. "DNA phosphorothioation is widespread and quantized in bacterial genomes." Proc Natl Acad Sci U S A 108, no. 7 (2011): 2963-8.
T Y Chan, Clement, Yan Ling Joy Pang, Wenjun Deng, Ramesh I Babu, Madhu Dyavaiah, Thomas J. Begley, and Peter C. Dedon. "Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins." Nat Commun 3 (2012): 937.
Mangerich, Aswin, Charles G. Knutson, Nicola M. Parry, Sureshkumar Muthupalani, Wenjie Ye, Erin Prestwich, Liang Cui, Jose L. McFaline, Melissa Mobley, Zhongming Ge et al. "Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer." Proc Natl Acad Sci U S A 109, no. 27 (2012): E1820-9.
Cao, Bo, Chao Chen, Michael S. DeMott, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent Butty, Stuart S. Levine, George Yuan et al. "Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences." Nat Commun 5 (2014): 3951.