Speaker:
Title:
Pumping the Brakes: Modulating Intratumoral Cytokine Signaling to Bolster Immunological Memory
Abstract:
Intratumoral cytokine therapies have emerged as an exciting platform to address unmet needs in cancer treatment. While capable of potently activating anti-tumor immune responses however, successful tumor clearance with cytokine therapies often comes at the expense of immunological memory. Here we present a counterintuitive result utilizing a blockade of inflammatory signaling to invigorate T cell stemness, bolstering immunological memory while enhancing tumor rejection.