A Stonefish-inspired Device for Oral Delivery of Biologics
Drug delivery by oral administration is the most common and patient-preferred route. Ingestible devices enable oral delivery of drugs previously only administered as injections, but the complexity of these devices may preclude them from clinical translation. Inspired by the efficient toxin delivery mechanism of the stonefish, we designed a simple, ingestible device enabling drug delivery with both high bioavailability and high reliability. We achieved platform drug delivery with the device in live pigs, paving the way for clinical translation.