Speaker:
Title:
Context-dependent Macrophage Repolarization
Abstract:
Macrophages adopt a wide functional diversity across nearly every tissue. However, recent breakthroughs have debunked the established model of unrestricted plasticity in macrophage differentiation. These restrictions on plasticity are not fully understood. Systematic network level analysis was used to characterize the landscape of macrophage fate decisions. Here, we show signals that restrict cell states which are crucial for pathogen clearance. We propose a conceptual framework to understand how macrophages integrate signals over time.