Quantifying Antigen Presentation Dynamics During Tumor Cell and Macrophage Evolution in Glioblastoma
Current immunotherapies fail to show efficacy in glioblastoma, due to the immunosuppressive tumor microenvironment (TME). In the TME, tumor cells and tumor associated macrophages cooperate to impede anti-tumor T cell response. To revert this immunosuppressive TME, understanding the dynamics of antigen presentation is important. We used immunopeptidomics to characterize cell-specific immunopeptidome shifts during macrophage and tumor cell interaction. We demonstrated that macrophage and tumor immunopeptidome co-evolves and identified targetable MHC-I peptides as potential therapeutics in GBM treatment.