Speaker:
Title:
DNA Nanostructures for Targeted Therapeutic Delivery
Abstract:
Targeted therapeutic delivery remains a significant challenge in nanomedicine. Nucleic acid nanoparticles are a promising nanomaterial for in vivo delivery that offer structural programmability, multivalent ligand presentation, multiplexed co-formulation of therapeutics, biocompatibility and controllable immunogenicity, and
scalable manufacturing. However, as their targeting and therapeutic capabilities have yet to be fully understood, a ligand receptor system in hepatocytes is being leveraged to explore these properties of DNA nanostructures.