Biophysical Characterization of Cytotoxic T cell Heterogeneity in Cancer Progression
Recent work has shown that T cell quality could be an indicator of immune checkpoint blockade response. We have seen previously that cells modulate their biophysical properties, such as mass, volume, and density, as they change states to optimize for certain functions. Could these properties potentially indicate the functionality of tumor infiltrating T cells? Here we aim to characterize cell function associated with different T cell buoyant mass ranges by combining novel cell sorting systems with downstream functional assays.