Speaker:
Title:
Mapping 3D Genome Architecture at Nucleosome Resolution with Tiled Micro-C
Abstract:
Chromosome conformation capture (3C) techniques
have uncovered 3D genomic structures spanning
the kb and Mb scales over the past two decades.
However, traditional techniques are ill-equipped to
map genomic microarchitecture at nucleosome resolution,
which is necessary to connect 3D genomic structures to their functions. Here,
we introduce Tiled Micro-C, a new 3C technique which overcomes these limitations by
mapping the 3D genome at unprecedented detail to unravel the functions of
the 3D genome.