Speaker:
Title:
Characterizing the Specificity Profile of a T cell Receptor
Abstract:
Targeted immunotherapies such as CAR T cell therapy and engineered TCR T cell therapy have made great advances in the treatment of a number of different cancers. However, reducing the cross-reactivity inherently expressed by T cell receptors has proven to be a limiting factor for TCR based therapies in the clinic. In this work, we aim to extensively characterize the specificity profile of a clinically relevant TCR and hypothesize that these data can be used to inform the design of a more precise peptide-MHC targeting TCR therapy.