Creating a New Malaria Vaccine by Displaying Antigens on the Parasite Surface
Current malaria vaccines utilize either subunit or whole-cell approaches and are inefficient in offering protection. I propose a combination, where a whole parasite serves as a chassis for protein presentation to reap the benefits of specific, chosen antigens on the parasite’s vacuolar membrane surface. Parasite lines were generated with conditional expression of protein fusions and characterized in and out of RBC hosts. This design could protect across the parasite life cycle to combat infection, growth, and transmission.