Identifying Regulators of Synaptogenesis with Optical Pooled Screens
Synaptogenesis, the formation of neuronal synapses, plays a critical role in shaping the connectivity and function of the nervous system. Dysregulation of this process has been implicated in autism, schizophrenia, and Alzheimer’s disease. Understanding the mechanisms underlying synapse formation therefore remains an outstanding goal in neurobiology. Here, we performed an image-based pooled screen to systematically map the regulatory networks driving this process, and identified novel molecular interactions in synaptogenesis.