Single-cell Analysis Reveals the Subthreshold TLR Response to Mycobacterium tuberculosis Infection
Tuberculosis remains a leading cause of infectious death globally. Recognition of Mycobacterium tuberculosis (Mtb) by host macrophages is primarily mediated by Toll-Like Receptor (TLR) 2. This work extends prior understanding of the regulation of TLR activity from the better-studied TLR4 to TLR2. Furthermore, we compared the extent to which soluble TLR2 ligands recapitulate host responses to Mtb, and how modulating this response affects Mtb clearance.