Identifying Correlates of Tuberculosis Protection Mediated by BCG in Collaborative Cross Mice
Tuberculosis is the leading cause of death by an infectious agent, and Mycobacterium tuberculosis currently infects a quarter of the world’s population. The only currently approved tuberculosis vaccine, BCG, has variable protection and the mechanisms by which it provides protection are not well understood. Furthermore, typical lab strains of mice do not model the diversity of responses observed in humans. Here, we begin to identify correlates of BCG-mediated protection in a genetically diverse cohort of mice called the Collaborative Cross.