Speaker:
Title:
Identifying Pathways that Control Cell Fate After DNA Damage
Abstract:
After DNA damage, cells must make a choice between three fates: continued proliferation, long-term cell cycle arrest, or programmed cell death. The information from many distinct signaling pathways needs to be integrated in order to commit to one of these fates, but how this occurs at the single-cell level is poorly understood. Using a combined transcriptomics and systems biology approach, we establish how the activity of multiple MAPK pathways modulate between these different outcomes after low doses of DNA damage.