BATS

Date/Time:

Sep 11, 2020 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Identifying Pathways that Control Cell Fate After DNA Damage

Abstract:

After DNA damage, cells must make a choice between three fates: continued proliferation, long-term cell cycle arrest, or programmed cell death. The information from many distinct signaling pathways needs to be integrated in order to commit to one of these fates, but how this occurs at the single-cell level is poorly understood. Using a combined transcriptomics and systems biology approach, we establish how the activity of multiple MAPK pathways modulate between these different outcomes after low doses of DNA damage.

Speaker:

Title:

Genome Mining for the Discovery of Modular Molecular Systems

Abstract:

CRISPR, TALEs, and antibodies are just a few examples of powerful biotechnologies that arose from the study of natural biochemical processes. At the same time, the rapid growth in genome sequencing has provided a new, immense resource for diverse organisms. We hypothesized that additional modular systems capable of performing new functions can be identified in silico from genome sequencing data. We present computational approaches for the discovery of new modular systems, and discuss a few example candidates from these searches.