BATS

Date/Time:

Feb 28, 2020 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Integrating Drug Distribution and Cellular Response to Better Understand Interpatient Heterogeneity

Abstract:

Many small molecule inhibitors fail in clinical trials, and response to these inhibitors varies between patients. A major underlying reason could be the limited drug distribution. More specifically, how the drug has distributed in the tumor and if it has even hit the target is not routinely evaluated. Here, we present an integrative platform where we combine mass spectrometry imaging (MSI), phosphoproteomics and cyclic immunofluorescence (CyCIF) to map drug distribution and measure cellular response to assess heterogeneous response to therapy.

Speaker:

Title:

Yeast Platform Technology for Sustainable Production of Molecules

Abstract:

Artificially photosynthetic systems aim to store solar energy and chemically reduce carbon dioxide. These systems have been developed in order to use light to drive processes for carbon fixation into biomass and/or liquid fuels. We have developed a hybrid-biological system that manages both genetically controlled generation of products along with the photoactivability of a semiconductor system. This work provides a basis on which to improve the production of many metabolites and products through endogenously produced nanoparticles.