BATS

Date/Time:

Feb 21, 2020 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Elucidating the Human Disease Relevance of Alzheimer’s Disease Mouse Models

Abstract:

While amyloid and tau pathology are defining characteristics of Alzheimer’s Disease (AD), they do not robustly correlate with disease severity. Nonetheless, amyloid and tau dysregulation are key features in most AD mouse models. To address this limitation, we developed a computational framework for translation of molecular/phenotype relationships. In this talk, I will discuss case studies using individual AD mouse models and our efforts to identify consensus, human AD-relevant transcriptomic signatures at the intersection of multiple models.

Speaker:

Title:

Engineered Phage for Theranostic Nanomedicine

Abstract:

In the Belcher lab, we are expanding on the functionality of M13 bacteriophage as an engineerable biomaterial. The phage consists of distinct protein subunits, which are amenable to mutation, and can be tuned for the binding and nucleation of materials and expression of targeting ligands or even enzymes. To harness these capabilities for medical imaging and therapy, a targeted and miniaturized M13 phage is considered here as a complete nanotheranostic that could augment the therapeutic efficacy of materials shuttled to the site of disease.