BATS

Date/Time:

Nov 15, 2019 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Multiscale, Multivariate Models of Complex Molecular and Cellular Phenotypes

Abstract:

Many are working on different ways to capture the multiscale nature of biology–by dynamic simulation, physical devices, or statistical modeling. Building off methods developed previously by Manu Kumar, we aim to analyze inter and intracellular signaling together to elucidate the different effects of several Kras mutants in colorectal cancer. Here, I showcase our use of scRNAseq and multiple statistical inference techniques to thoroughly characterize cell-cell communication of the tumor microenvironment and discuss my work on a future project.

Speaker:

Title:

The Genetic Architecture of Pathogen-specific Humoral Responses

Abstract:

The pressure of the host-pathogen relationship resulted in a selection on the population scale that has given rise to a range of genes that determine effective responses. The mechanisms and genetics that determine the composition of polyclonal antibodies that drive immune function in a pathogen-specific manner are not well understood. Therefore, systematically profiling the antibody characteristics and functions of a cohort of twins to estimate heritability and map genetic loci can reveal the genetic architecture that underpins variation.