Speaker:
Title:
Multiscale, Multivariate Models of Complex Molecular and Cellular Phenotypes
Abstract:
Many are working on different ways to capture the multiscale nature of biology–by dynamic simulation, physical devices, or statistical modeling. Building off methods developed previously by Manu Kumar, we aim to analyze inter and intracellular signaling together to elucidate the different effects of several Kras mutants in colorectal cancer. Here, I showcase our use of scRNAseq and multiple statistical inference techniques to thoroughly characterize cell-cell communication of the tumor microenvironment and discuss my work on a future project.