Investigating the Mechanism of Action of Anti-fibrotic Biomaterials
The foreign body response to implantable biomaterials is a significant challenge in the long-term success of medical devices. The host response can be detrimental to device function due to inflammation and fibrotic capsule formation. To address this challenge, our lab screened materials to identify those that mitigate the foreign body response in mice. We are now working to identify the mechanism of action of the lead materials from this screen to improve our understanding of the foreign body response and rationally design new materials.