Nanolayered Surface Coatings for Programmable Gene Delivery in Cranial Bone Repair
Clinical repair of cranial bone defects using biological or metal grafts is limited by tissue availability or poor functional bone restoration. Full regeneration of mature bone requires timed introduction of growth factors involved in natural fracture healing. Our research aims to develop an implant coating for programmed gene delivery to stimulate in situ osteogenic growth factor expression and enhance bone repair. This talk describes approaches to construct a gene-delivering film and factors affecting delivery efficacy.