Small Molecule Screening Against the Oncogenic Pluripotency Factor LIN28
Oncogenic signals frequently converge on a set of core regulatory factors which confer the phenotypic plasticity required for cancer cell survival and proliferation. These factors are established cancer dependencies, but are phenomenally difficult to drug. Recent work has clarified the role of LIN28 in stabilizing these factors and as a contributor to oncogenic reprogramming. This work aims to develop assays for the discovery of LIN28 - small molecule interactions and to apply these new ligands to the development of chemical probes for LIN28.