Characterizing Signaling Dynamics in Response to Environmental Pollutants
Increased exposure to contaminants like polycyclic aromatic hydrocarbons (PAHs) have put people at a higher risk of developing chronic complications. Despite decades of research, pathways underlying the cellular response to these contaminants are still poorly understood. This work aims to apply a systems biology approach to elucidate the molecular and cellular response to PAHs at physiologically relevant dose and time regimens. Here, we quantify tyrosine phosphorylation signaling and DNA damage response pathways at the systems level.