Speaker:
Title:
Understanding and Mitigating the Effects of Limited Transcriptional Resources in Mammalian Cells
Abstract:
Complex synthetic biological networks that can read and respond to molecular inputs as cells change state or produce important biomolecules have the potential to transform medicine and biology. However, implementing such complex networks requires well-characterized, orthogonally-acting biological parts that function consistently in diverse cellular contexts. To address this need, we have developed a scalable quasi-integral feedback control device which reduces the effects of cellular noise and mitigates resource competition between our parts.