BATS

Date/Time:

Mar 9, 2018 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Understanding and Mitigating the Effects of Limited Transcriptional Resources in Mammalian Cells

Abstract:

Complex synthetic biological networks that can read and respond to molecular inputs as cells change state or produce important biomolecules have the potential to transform medicine and biology. However, implementing such complex networks requires well-characterized, orthogonally-acting biological parts that function consistently in diverse cellular contexts. To address this need, we have developed a scalable quasi-integral feedback control device which reduces the effects of cellular noise and mitigates resource competition between our parts.

Speaker:

Title:

Colonization Dynamics of E. faecalis in Implanted Research Macaques Over a Multi-year Period

Abstract:

Macaques are the most commonly non-human primate used in cognitive neuroscience research. Neurophysiology research commonly involves surgical implantation of cephalic recording chambers (CRCs), which are frequently colonized by bacteria. This talk will cover findings from our preliminary microbiota analysis of CRC exudate, and discuss changes in sequence type, antimicrobial resistance, virulence, and hypermutability in populations of Enterococcus faecalis over time.