BATS

Date/Time:

Dec 1, 2017 - 12:00 PM

Location:

Hosts:

Bevin P. Engelward

Speaker:

Title:

Nanolayer Surface Coatings for Programmable Gene Delivery in Cranial Bone Repair

Abstract:

Clinical repair of cranial bone defects using biological or metal grafts are limited by tissue availability or poor functional bone restoration. Full regeneration of mature bone requires timed introduction of growth factors involved in natural fracture healing. Our research aims to develop an implant coating for programmed gene delivery to stimulate in situ osteogenic growth factor expression and enhance bone repair. This talk describes approaches to construct a gene-delivering film and factors affecting delivery efficacy.

Speaker:

Title:

Nanoparticle Delivery of Innate Immune Activating Cancer Immunotherapy

Abstract:

Stimulation of the innate immune system has become an attractive strategy for overcoming the immunosuppressive tumor microenvironment. Agonists of the stimulator of interferon genes (STING) pathway, which trigger innate immune activation, can induce durable antitumor responses. However, this drug class generates widespread inflammation – a serious safety concern for patients. This work explores the use of nanoparticles to restrain STING agonists within tumors, target uptake to innate immune cells, and direct subcellular localization.