BATS

Date/Time:

May 20, 2016 - 12:00 PM

Location:

Hosts:

Bevin P. Engelward

Speaker:

Title:

Combination Immunotherapy Engaging Innate and Adaptive Immunity

Abstract:

Checkpoint blockade has shown that endogenous immune responses can elicit durable regressions in advanced tumors, but these responses are confined to a minority of patients. This outcome is partly due to the network of immunosuppressive pathways present in advanced tumors, which are unlikely to be overcome by intervention at a single checkpoint. Generating a counter-directed network of pro-immunity signals through combination immunotherapies may be a powerful strategy for improving efficacy of immunotherapies in the clinic.

Speaker:

Title:

Mechanical Modulation of the Mesenchymal Stromal Cell Secretome for Hematopoietic Recovery

Abstract:

Human mesenchymal stromal cells (hMSCs) play an important role in indirect repair through pro-angiogenic and immunomodulatory signaling. In previous studies, we isolated a specific subpopulation of hMSCs that supports regeneration of the bone marrow in vivo, but is limited in cell number. We leverage cell substratum mechanics to modulate the secretome of the entire hMSC population. The altered secretome mimics the secretome of the subpopulation that promotes hematopoietic recovery and we validate its effects using in vitro co-culture.