Speaker:
Title:
A Yeast Display/Secretion System for the Rapid Generation of Renewable Recombinant Abs
Abstract:
Many commercial antibodies fail to perform as desired in
laboratory assays, and the process of generating new antibodies can be a
long, risk-filled process. Here we present a yeast display based system to
facilitate the rapid isolation of validated antibody-like constructs in as
little as one month. This system is able to both display antibody on the
surface of yeast, suitable for binder isolation and characterization, as well
as secrete antibody, allowing for cloning-free expression of promising
candidates.