BATS

Date/Time:

Feb 19, 2016 - 12:00 PM

Location:

Hosts:

Bevin P. Engelward

Speaker:

Title:

Image-based Temporal Modeling of Morphology Dynamics for Profiling Live-Cell Phenotypes

Abstract:

As the use of live-cell imaging continues to grow, new tools are needed to objectively characterize, compare, and classify dynamic cellular responses to external perturbations. I will present a framework that combines live imaging, image processing and analysis, and temporal modeling, to characterize cell shape dynamics from high-content time series imaging data. This framework can be used as a phenotypic drug profiling tool and enables hypothesis generation for mechanistic follow-up studies.

Speaker:

Title:

Sono-Fragmentation of 1D Materials for Synthesis of Ultra-small Nanoparticles

Abstract:

Ultra-small (<10nm) inorganic nanoparticles have interesting physical properties that can be useful for probing biology. However, their current utilization is limited owing to complex, expensive and often hazardous processes that are involved in their synthesis. Here we report a facile and high-yield method based on ultrasonic fragmentation of 1D/nanowire substrates that overcomes most of these limitations and apply it to the synthesis of germanium nanocrystals. We further show this method can be generalized to oxide and metal nanoparticles.