Speaker:
Title:
Engineering Physiologically Relevant Models of Hepatic Insulin Resistance
Abstract:
Hepatic insulin resistance is a major feature of the progression of metabolic disorders, including nonalcoholic fatty liver disease and type 2 diabetes. However, much remains to be understood about the interplay between molecular and cellular cues driving insulin resistance establishment. Here, we present progress towards improved in vitro liver insulin resistance models, utilizing primary human 3D cell culture and physiologically relevant media conditions, for advancing our understanding of the mechanisms of disease.