BATS

Date/Time:

Oct 22, 2021 - 12:00 PM

Location:

32-155, Hybrid

Hosts:

Bevin Engelward

Speaker:

Title:

Engineering Physiologically Relevant Models of Hepatic Insulin Resistance

Abstract:

Hepatic insulin resistance is a major feature of the progression of metabolic disorders, including nonalcoholic fatty liver disease and type 2 diabetes. However, much remains to be understood about the interplay between molecular and cellular cues driving insulin resistance establishment. Here, we present progress towards improved in vitro liver insulin resistance models, utilizing primary human 3D cell culture and physiologically relevant media conditions, for advancing our understanding of the mechanisms of disease.

Speaker:

Title:

Enzymatic Programming of Intratumoral Reactive Oxygen Species to Enhance Immunotherapy

Abstract:

Increased cellular levels of reactive oxygen species (ROS) are observed as a result of many cancer cytotoxic treatments, despite only a fraction of them leading to the release of danger signals common to immunogenic cell death (ICD). As such, modulating the spatiotemporal dynamics of intratumoral ROS levels may enable the immunogenicity of tumor cell death to be tuned. Here, we examine the use of oxidase enzymes as an approach to probe ROS-ICD relationships and design treatment combinations that achieve stronger anti-tumor immunity.