Elizabeth Choe (WHITE LAB)

Identifying Intracellular Networks Related to Antigen Presentation in Glioblastoma

How do cancer cells convert an external perturbation into an interaction with the immune system? This process remains largely unknown, but understanding it could be crucial for improving outcomes to immunotherapies in cancers like glioblastoma. I will share my on-going work characterizing how various therapies alter kinase signaling networks within glioblastoma cells, how they alter the repertoire of antigens glioblastoma cells present to the immune system, and the relationship between these changes.

Richard Wu (MANALIS LAB)

Making Sense of Mass – an Ongoing Story on T Cell Buoyant Mass Heterogeneity

Biophysical properties such as cell mass, volume, and density are some of the fundamental metrics of the cellular state. For decades, bulk methods have enabled us to characterize various cell types in peripheral blood. But they lack the resolution to uncover biophysical heterogeneity within particular cell types. Utilizing a suspended microcantilever system (SMR), we profiled single-cell buoyant mass and density in the circulating T cell populations and discovered unexpected separations of biophysical states.