Katherine Ilia (WEISS LAB)

Synthetic Genetic Feedback Control Circuits to Reprogram Cell Fate

Induced pluripotent stem cells hold immense potential for personalized regenerative medicine. However, after almost fifteen years of exceptional progress, somatic cell reprogramming efficiency and resultant cell quality are still low. We hypothesize that the ability to regulate key transcription factor (TF) levels is critical for successful reprogramming. In this talk, we will discuss recent work to develop novel genetic controllers that facilitate precise steering of TF levels and their application towards improving reprogramming efficiency.

Aimee Moise (ENGELWARD LAB)

The Effect of a Probiotic on Mutations Induced by a Methylating Agent

Cancer is caused by accumulated mutations, and chemicals that alter DNA structure can lead to mutations that promote cancer. Methylating agents are an important class of carcinogens that are present in pollution and food, and they can even be endogenously produced. We are interested in strategies for reducing DNA damage-induced mutations as a potential avenue toward cancer prevention. Here, I will present results from studies exploring the impact of a probiotic on mutations.