Speaker:
Title:
Synthetic Genetic Feedback Control Circuits to Reprogram Cell Fate
Abstract:
Induced pluripotent stem cells hold immense potential for personalized regenerative medicine. However, after almost fifteen years of exceptional progress, somatic cell reprogramming efficiency and resultant cell quality are still low. We hypothesize that the ability to regulate key transcription factor (TF) levels is critical for successful reprogramming. In this talk, we will discuss recent work to develop novel genetic controllers that facilitate precise steering of TF levels and their application towards improving reprogramming efficiency.