Engineering Probiotics for the Modulation of Bile Acid Metabolism
The gut microbiota synthesize hundreds of metabolites that influence host physiology. Among these metabolites, bile acids are highly abundant and regulate essential host processes. Given the close interplay between bile acids and host physiology, several disease states are associated with the dysregulation of bile acid pools. We propose to develop engineered probiotic bacteria that reconstitute and modulate bile acid biosynthesis in the gut, thereby facilitating bile acid host-interaction studies and therapeutic efforts.