Mechanistic Characterization of the Epidermal Growth Factor Receptor Signaling Network
Dysregulated in many cancers, the epidermal growth factor receptor (egfr) heavily relies on tyrosine phosphorylation for signal transduction. Despite widespread efforts in targeting egfr, results in the clinic have been mixed due to a lack of understanding of the individual roles of its tyrosine residues. Here, we present a phosphoproteomic approach to study the signaling network using a site-specific model. Our dataset highlights the resilience of this system as well as components of the network we may leverage in future targeting strategies.