BATS

Date/Time:

Sep 4, 2020 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Wearable Cell-Free Synthetic Biology

Abstract:

Wearable biosensors have become increasingly relevant as promising solutions for monitoring of disease states and pathogen/toxin exposure. The integration of synthetic biology tools into such formats could improve and expand on this potential. Here, we report on the development of a novel wearable sensing platform based on cell-free synthetic biology reactions freeze-dried into flexible substrates and textiles.

Speaker:

Title:

Screening for Lethality: Discovering Therapeutic Strategies Against Antibiotic Tolerant Bacteria

Abstract:

Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays an important role in the disease burden of bacterial infections. However, antibiotic screens typically rely on growth inhibition as a readout and thus do not inform on the lethal component of compound bioactivity. Here we show the development of screening methods to report on the killing of antibiotic-tolerant bacteria and the discovery of prospective therapeutic strategies to counter antibiotic tolerance.