Elucidating the Peptide Repertoire of Non-canonical Class Ib MHCs
Major histocompatibility complex proteins (MHCs) are key to enabling adaptive immune surveillance. Canonical MHCs are also the most polymorphic genetically-encoded proteins in humans, which presents challenges in developing immunotherapies that work across patient populations. In contrast, non-canonical class Ib MHCs are highly conserved among all people, potentially enabling the design of generalizable immunotherapies. Here, I will discuss our work elucidating the class Ib peptide-binding repertoire and potential therapeutic applications.