Speaker:
Title:
Understanding Pathway Integration and Cell Fate Control After DNA Damage
Abstract:
After DNA damage, cells can either proliferate, undergo cell death, or enter a senescent state. Multiple survival and stress signaling pathways need to integrate information at the single-cell level to choose amongst these phenotypic outcomes. Here I present data implicating multiple MAP Kinase pathways as modulators of cell fate, and discuss the development of a multi-omics experimental and computational approach to better understand potential signaling mechanisms that differentiate cell fates under heterogeneous contexts.