Speaker:
Title:
Using Metabolic Responses to Antibiotics to Rationally Design Drug Combinations
Abstract:
Antibiotic combinations are often used to increase treatment efficacy or overcome antibiotic resistance, but drug interaction mechanisms and their context dependence remain poorly understood. Because bacterial metabolism is broadly altered by antibiotic action and also affects antibiotic efficacy, the goal of my project is to explore how metabolic responses to individual antibiotics affect drug interactions. This work can inform optimal drug pairings and the environmental conditions in which they will be most effective.