Identification of Dysregulated Signaling Events in Medulloblastoma
Medulloblastoma (MB) is the most common malignant pediatric brain cancer; and, even though previous studies helped us define the genomic and transcriptomic landscapes of this disease, no successful targeted therapies have been identified. We believe this can be attributed to a lack of mechanistic insights. Our group, therefore, studies different kinds of signaling molecules directly. This talk will give an overview of our efforts to identify dysregulated and potentially targetable signaling events in MB and its subtypes.