Epitranscriptomics: A System of tRNA Modifications Control Mycobacterial Drug Resistance
My research aims to advance our fundamental understanding of how translation regulates cell phenotype. I am developing a translational model for how Mycobacterium tuberculosis, the world’s more pervasive pathogen, survives the stress of infection. Integrating in-house methods to study post-transcriptional biology with quantitative proteomics and whole-genome codon usage analysis, I have identified tRNA modification enzymes as potential antibiotic targets. Ultimately, my work looks to establish a general approach for anti-infectives discovery.