Computational Identification of Drug Targets for Complement System Diseases
The complement system is a set of proteins in the circulation that activate in the presence of pathogens and provoke an immune response. Dysregulation of complement plays a role in various inflammatory diseases. We developed a computational model of the complement system to study the effects of a hypothetical panel of antibody therapeutics on complement activation in kidney diseases. Simulations reveal simple yet easily overlooked principles of target selection and suggest important sources of inter-patient variability and drug synergy.