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October 31, 2025 Seminar
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											  Sarah SobolWittrup Lab DeKosky LabG protein-coupled receptors (GPCRs) already form the largest class of drug targets, but there is increased interest in developing GPCR targeting antibodies. This remains challenging due to the diversity of GPCR signal transduction cascades and many high-throughput screening technologies focusing on binding instead of function. We are applying single-cell droplet technologies and an arrestin recruitment assay to develop a generalizable high-throughput functional screening platform in order to identify agonist and antagonist antibodies for GPCRs. 
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											  Nickeisha CuthbertNiles LabPlasmodium falciparum is the deadliest cause of human malaria. Although front-line antimalarials like artemisinin (ART) have significantly reduced the malaria burden, cases of P. falciparum parasites that survive ART exposure are increasing. Dysregulation of the Pfkelch13 gene is implicated in ART resistance, though its precise function within the parasite remains unclear. We utilized a conditional knockdown (cKD) system in an assay designed to modulate Pfkelch13 expression and assess the effect on P. falciparum survival and resistance to ART. 
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