Seminars

G protein-coupled receptors (GPCRs) already form the largest class of drug targets, but there is increased interest in developing GPCR targeting antibodies. This remains challenging due to the diversity of GPCR signal transduction cascades and many high-throughput screening technologies focusing on binding instead of function. We are applying single-cell droplet technologies and an arrestin recruitment assay to develop a generalizable high-throughput functional screening platform in order to identify agonist and antagonist antibodies for GPCRs.