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April 17, 2026 Seminar
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Rachel McGinn
Bryson LabMycobacterium tuberculosis (Mtb) is the deadliest infectious agent worldwide, yet developing a broadly protective vaccine remains challenging. Both CD4 and CD8 T cells contribute to control of Mtb infection. CD8 T cell activation depends on MHC-I presentation of bacterial peptides, but how Mtb antigens access this pathway is unclear. Prior work from our lab showed that mutation of ESX-1, a type VII secretion system, disrupts MHC-I presentation of bacterial peptides. Here, we investigate the role of ESX-1 in Mtb antigen presentation.
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James Jusuf
Hansen LabChromatin looping is essential for proper gene regulation, and its dysfunction is associated with cancer and other genetic diseases. Recent evidence suggests that chromatin loops are rare, fleeting structures, but this has not been studied on a genome-wide scale. We combine Micro-C and live imaging, two methods with complementary strengths, to estimate the absolute looping probabilities of 60,000+ loops across the mouse genome. We also analyzed the effects of different mechanisms and epigenomic factors on absolute looping probability.
